Biomarkers.

Background: Early detection of Mild Cognitive Impairment (MCI) is crucial for effective prevention. Traditional methods like expert judgment, clinical evaluations, and manual linguistic analyses are now complemented by Artificial Intelligence (AI). AI offers new avenues for identifying linguistic, facial, and acoustic markers of MCI.

Biomarkers.

Background: With the increase in life expectancy and the rising prevalence of Alzheimer's Disease (AD), the integration of biomarkers for early diagnosis is crucial. The Mayo Preclinical Alzheimer's Cognitive Composite (Mayo-PACC), encompassing the Rey-Auditory Verbal Learning Test (RAVLT), Trail Making Test - B (TMT B), and semantic fluency, is designed to detect cognitive changes in preclinical AD. This study investigates gender-based differences in the predictive efficacy of Mayo-PACC for AD biomarkers following the ATN (Amyloid, Tau, Neurodegeneration) criteria.

Dementia Care Research and Psychosocial Factors.

Background: Dementia represents a significant health challenge, with evidence suggesting that it can be potentially delayed or prevented through non-pharmacological interventions. There are different types of non-pharmacological interventions for Mild Cognitive Impairment (MCI). The Aging Well through Interaction and Scientific Education (AgeWISE) Program is a notable cognitive intervention designed to educate both individuals experiencing normal aging and those with age-related diseases.

Dementia Care Research and Psychosocial Factors.

Background: LatAm-FINGERS - the first non-pharmacological multicenter randomized clinical trial in Latin America - is a valuable opportunity to study lifestyle in a heterogeneous and multiethnic population exposed to a large number of cardiovascular risk factors. Our aims are to study the risk distribution in the LatAm-FINGERS cohort and to explore the relationship between LIfestyle for BRAin Health (LIBRA) and cognition.

Method: We calculated the risk of dementia using the LIBRA score in the entire cohort (n = 1200).

Impact of COVID-19 on functional, cognitive, neuropsychiatric, and health-related outcomes in patients with dementia: A systematic review.

Background: This systematic review analyzes the impact of COVID-19 on dementia patients' functional, cognitive, neuropsychiatric, and health related outcomes. It hypothesizes that dementia patients infected with SARS-CoV-2experience more pronounced deterioration compared to those who are uninfected.

Methods: Research from 01/03/2020 to 07/10/2023 was conducted using Medline, Web of Science, and Embase databases, and adhering to PRISMA guidelines and the PICO framework.