Sofia profile plot: a new graphical approach to present the changes of hearing thresholds with time.

After pure-tone audiometry, we have several sequences of threshold values. Usually, a multiple-line plot is used to present and compare data between measurements by overlaying them in a single graph. Calculation of air-bone gap and pure-tone average is widely accepted as an approach to simplify statistical handling of these data.

Antimeasles immunoglobulin G and virus-neutralizing activity in sera of patients with otosclerosis.

Otosclerosis is considered as an organ-specific measles virus (MV)-induced disease. The majority of people are infected with MV during childhood, and the immune activation is characterized by a lifelong persistence. Any kind of depressed systemic antimeasles reaction can lead to induction of a local immune response in the inner ear.

Decreased measles virus-neutralizing activity in sera from otosclerotic patients.

Hypothesis: Any kind of depressed systemic anti-measles reaction can lead to the induction of a local immune response in the inner ear and possibly to reactivation of bone turnover in this region.

Methods: Different dilutions of sera were tested for neutralizing activity against a constant viral concentration. The ability of measles virus to infect and replicate in the cell monolayer was detected by enumeration of living and growing cells with a colored reaction.

Antimeasles immunoglobulin G in sera of patients with otosclerosis is lower than that in healthy people.

Background: There is some evidence for an inflammatory process as a driving force in otosclerosis. Two popular hypotheses for the induction of this chronic inflammation have been proposed: an autoimmune phenomenon induced by an otic capsule specific antigen and measles virus infection.

Methods: Antibodies against measles virus hemagglutinin, polymerase, nucleocapsid, and matrix proteins were evaluated in sera from otosclerotic patients and in sera from healthy age-and sex-matched controls by use of the Western blot analyses.