Publications by authors named "G Dveksler"
Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20-23 September 2024. Würzburg, Germany.
Eur J Clin Invest
December 2024
Successful pregnancy relies on a coordinated interplay between endocrine, immune, and metabolic processes to sustain fetal growth and development. The orchestration of these processes involves multiple signaling pathways driving cell proliferation, differentiation, angiogenesis, and immune regulation necessary for a healthy pregnancy. Among the molecules supporting placental development and maternal tolerance, the families of pregnancy-specific glycoproteins and galectins are of great interest in reproductive biology.
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- Placental abnormalities can lead to issues like preeclampsia (PE), impacting both the mother's health and fetal growth.
- Galectin-1 (gal-1) is a crucial protein at the maternal-fetal interface that helps regulate pregnancy adaptations and placental development.
- A deficiency of gal-1, especially from the mother, increases the risk of PE and disrupts normal placental function, suggesting that problems with gal-1 signaling might contribute to pregnancy complications and maternal cardiovascular issues.
Article Synopsis
- - The SARS-CoV-2 pandemic posed significant risks to pregnant women and newborns, highlighting the importance of the maternal immune system in managing infections while supporting fetal growth.
- - Galectins, proteins that play a role in immune regulation, are essential for successful pregnancies, with recent studies indicating their involvement in the immune response to SARS-CoV-2 infection.
- - In the study, maternal levels of galectin-1 increased with SARS-CoV-2 infection, while pregnancy-specific glycoprotein 1 levels rose only during infection; the research reveals a complex relationship between these proteins and pregnancy health during the pandemic.
Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background knowledge on coronaviruses developed over decades by researchers, including Kathryn (Kay) Holmes. Kay's research team discovered the first coronavirus receptors for mouse hepatitis virus and human coronavirus 229E and contributed a wealth of information on coronaviral spike glycoproteins and receptor interactions that are critical determinants of host and tissue specificity.
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