Publications by authors named "G Duranti"
Skeletal muscle tissue can regenerate after damage through the action of satellite cells, which proliferate as myoblasts when activated. Oxidative stress, marked by high rates of reactive oxygen species (e.g.
View Article and Find Full Text PDFCancer remains a major challenge in medicine, prompting exploration of innovative therapies. Recent studies suggest that exercise-derived extracellular vesicles (EVs) may offer potential anti-cancer benefits. These small, membrane-bound particles, including exosomes, carry bioactive molecules such as proteins and RNA that mediate intercellular communication.
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- - Biological age is a more accurate reflection of health than chronological age, and a study shows that a 16-week online physical activity program can significantly reduce biological age in breast cancer survivors post-surgery.
- - Although telomere length remained unchanged, the ELOVL2 epigenetic clock indicated that participants in the physical activity group experienced a reduction in biological age, linked to improvements in cardiovascular fitness and strength.
- - The study suggests that incorporating physical activity can support better recovery for breast cancer patients and highlights the potential of epigenetic clocks as a tool to assess health status and identify at-risk individuals.
is widely grown throughout the tropics and increasingly used for its therapeutic and nutraceutical properties. These properties are attributed to potent antioxidant and metabolism regulators, including glucosinolates/isothiocyanates as well as flavonoids, polyphenols, and phenolic acids. Research to date largely consists of geographically limited studies that only examine material available locally.
View Article and Find Full Text PDFMost anticancer treatments act on oxidative-stress pathways by producing reactive oxygen species (ROS) to kill cancer cells, commonly resulting in consequential drug-induced systemic cytotoxicity. Physical activity (PA) has arisen as an integrative cancer therapy, having positive health effects, including in redox-homeostasis. Here, we investigated the impact of an online supervised PA program on promoter-specific DNA methylation, and corresponding gene expression/activity, in 3 antioxidants- (SOD1, SOD2, and CAT) and 3 breast cancer (BC)-related genes (BRCA1, L3MBTL1 and RASSF1A) in a population-based sample of women diagnosed with primary BC, undergoing medical treatment.
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