Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection.

Three separate studies, two involving active-immunization regimens and one involving a passive-transfer protocol, were conducted to initially screen and ultimately more fully assess several nontypeable Haemophilus influenzae outer membrane proteins or their derivatives for their relative protective efficacy in chinchilla models of otitis media. Initial screening of these antigens (P5-fimbrin, lipoprotein D, and P6), delivered singly or in combination with either Freund's adjuvant or alum, indicated that augmented bacterial clearance from the nasopharynx, the middle ears, or both anatomical sites could be induced by parenteral immunization with P5-fimbrin combined with lipoprotein D, lipoprotein D alone, or the synthetic chimeric peptide LB1 (derived from P5-fimbrin), respectively. Data from a second study, wherein chinchillas were immunized with LB1 or lipoprotein D, each delivered with alum, again indicated that clearance of nontypeable H.

[Urinary infection in the pregnant woman].

Urinary tract infections are common during pregnancy. When unrecognized, they can be responsible for complications such as threatened premature labour and impaired intra-uterine development. Detection and appropriate treatment are thus essential.

[A giant cyst of the seminal vesicle associated with ipsilateral uretero-renal agenesis].

The authors present a case of seminal vesicle cyst and discuss the polymorphic clinical features and the examinations required to establish the diagnosis. Treatment is surgical and reserved to cysts with severe symptoms.

[Leiomyoma of the bladder].

The authors report a case of bladder leiomyoma. They emphasise its rarity and the important role of medical imaging in its preoperative diagnosis, which can only be confirmed with certainty by histological examination. Treatment must be surgical with complete resection and the prognosis is excellent.

[Eosinophilic bladder disease].

The authors present ten cases of eosinophil cystopathy and recall the very varied clinical signs of this disease: pollakiuria, haematuria, dysuria and the findings of complementary investigations: possible dilatation of the upper urinary tract, thickening of the bladder wall. Biopsy is essential and reveals lymphocyte and plasma cell infiltration and numerous eosinophils. The treatment administered was either immunosuppressants or dimethyl sulphoxide.