Publications by authors named "G Dupont"
Background: Stress due to surgical trauma decreases postoperative lymphocyte counts (LCs), potentially favouring the occurrence of postoperative infections (PIs).
Objectives: We aimed to determine whether postoperative lymphopaenia following thoracic or gastrointestinal cancer surgery is an independent risk factor for PIs and to identify modifiable factors related to anaesthesia and surgical procedures that might affect its occurrence.
Study Design: The EVALYMPH study was a prospective, multicentre cohort study with a 30-day patient follow-up.
Introduction: Hepatitis C (HCV) is one of the major worldwide infections with 58 million infected persons in the world. HCV can lead to chronic liver disease, cirrhosis, and cancer. These past few years, clinical progress allowed a curative rate of 95% of the patients.
View Article and Find Full Text PDFCa puffs underlie adhesion-triggered Ca microdomains in T cells.
Biochim Biophys Acta Mol Cell Res
December 2024
Ca signalling is pivotal in T cell activation, an essential process in adaptive immune responses. Key to this activation are Ca microdomains, which are transient increases in cytosolic Ca concentration occurring within narrow regions between the endoplasmic reticulum (ER) and the plasma membrane (PM), lasting a few tens of milliseconds. Adhesion Dependent Ca Microdomains (ADCM) rely on store-operated Ca entry (SOCE) via the ORAI/STIM system.
View Article and Find Full Text PDFArticle Synopsis
- Recent findings indicate that biallelic WARS2 pathogenic variants lead to a partial aminoacylation defect, linked to late-onset conditions like dopa-responsive dystonia parkinsonism and myoclonus ataxia.
- * The case study describes a 39-year-old male with a history of childhood-onset progressive dystonia, psychiatric symptoms, and ataxia, where genome sequencing revealed specific variants that confirmed a WARS2-related disease diagnosis.
- * The identified missense variant (p.(Trp13Gly)) is associated with milder symptoms compared to severe loss-of-function variants, reinforcing the relationship between genotype and phenotype in these disorders.
Article Synopsis
- - Clozapine-induced myocarditis (CIM) is a serious side effect of clozapine treatment for schizophrenia, requiring immediate discontinuation of the drug, which can negatively affect patients' mental health and long-term outcomes.
- - There is growing interest in safely reintroducing clozapine after CIM, with a reported success rate of around 60%, yet research and case reports on this re-challenge process are still limited.
- - The review covers CIM's epidemiology, risks, and management, recommending cautious re-challenge strategies that involve slow dose increases and monitoring key biomarkers to prevent recurrence and ensure patient safety.