Publications by authors named "G Dumitriu"
Liver sinusoidal endothelial cells (LSECs) which make up the fenestrated wall of the hepatic sinusoids, are active scavenger cells involved in blood waste clearance and liver immune functions. Dexamethasone is a synthetic glucocorticoid commonly used in the clinic and as cell culture supplement. However, the response is dependent on tissue, cell type, and cell state.
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- - Liver sinusoidal endothelial cells (LSECs) play a crucial role in clearing waste from blood, but their function is affected in liver disease, particularly in Glmpgt/gt mice, which show chronic liver injury and fibrosis.
- - A study using FITC-labelled serum albumin demonstrated that LSECs in Glmpgt/gt mice have significantly reduced capacity for scavenging compared to wild-type mice, even though certain scavenger receptor expressions remained similar.
- - Despite the presence of increased collagen and liver damage, LSECs in Glmpgt/gt mice maintained well-formed fenestrae, though with a higher frequency of larger openings, indicating alterations in structure but not a complete loss of function.
Mitophagy is the degradation of surplus or damaged mitochondria by autophagy. In addition to programmed and stress-induced mitophagy, basal mitophagy processes exert organelle quality control. Here, we show that the sorting and assembly machinery (SAM) complex protein SAMM50 interacts directly with ATG8 family proteins and p62/SQSTM1 to act as a receptor for a basal mitophagy of components of the SAM and mitochondrial contact site and cristae organizing system (MICOS) complexes.
View Article and Find Full Text PDFThe liver is constantly exposed to dietary antigens, viruses, and bacterial products with inflammatory potential. For decades cellular uptake of virus has been studied in connection with infection, while the few studies designed to look into clearance mechanisms focused mainly on the role of macrophages. In recent years, attention has been directed towards the liver sinusoidal endothelial cells (LSECs), which play a central role in liver innate immunity by their ability to scavenge pathogen- and damage-associated molecular patterns.
View Article and Find Full Text PDFNeuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity and late effects. Spleen tyrosine kinase (SYK) has previously been identified as a promising drug target in various inflammatory diseases and cancers but has so far not been extensively studied as a potential therapeutic target in neuroblastoma.
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