Publications by authors named "G Duhamel"
Article Synopsis
- Tick-borne infections, particularly Lyme disease, are on the rise in the U.S. and globally, with varying severity from mild to severe symptoms.
- In a study using susceptible B6 mice, co-infection with Lyme disease and another pathogen caused significant inflammatory responses and joint inflammation, unlike single infections.
- The results indicate that co-infection can worsen Lyme disease's impact, leading to more severe inflammation and joint issues.
Quantitative MRI (qMRI) has been shown to be clinically useful for numerous applications in the brain and body. The development of rapid, accurate, and reproducible qMRI techniques offers access to new multiparametric data, which can provide a comprehensive view of tissue pathology. This work introduces a multiparametric qMRI protocol along with full postprocessing pipelines, optimized for brain imaging at 3 Tesla and using state-of-the-art qMRI tools.
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- Canine oral squamous cell carcinoma (COSCC) is a common and aggressive oral tumor in dogs, with a significant risk of metastasis at diagnosis.
- The typical treatment involves wide surgical excision, which can have a considerable impact on a dog's quality of life.
- Recent research shows that the MEK inhibitor trametinib, an FDA-approved drug for human cancers, effectively reduces COSCC cell growth and may lead to tumor regression in some canine patients, offering new hope for better treatment options.
Differentiating canine acanthomatous ameloblastoma (CAA) from oral squamous cell carcinoma (OSCC) based on routine histopathology can be challenging. We have previously shown that more than 95% of CAAs harbor an p.Q61R somatic mutation, while OSCCs carry either wild-type alleles or other MAPK pathway activating mutations (e.
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