CLINICAL AND GENETIC PREDICTORS AND PROGNOSTIC MODEL OF RAPIDLY PROGRESSIVE HEPATIC FIBROSIS IN CHRONIC HEPATITIS C.

The search for risk factors for rapid progression of hepatic fibrosis (HF) in chronic hepatitis C (CHC) is a topical scientific and practical task. The purpose of the study is to identify clinical and genetic predictors and create the prognostic model of rapidly progressive HF in CHC. A retrospective cohort study of 125 patients with CHC has been carried out.

[THE ROLE OF GENETIC POLYMORPHISMS TOLL-LIKE RECEPTOR 4 AND 7 IN THE CHRONIC HEPATITIS C AND GENDER FEATURES OF THEIR DISTRIBUTION].

The aim of the study was to investigate the prevalence of polymorphisms Asp299Gly (rs4986790) TLR4 gene and Gln11Leu (rs179008) TLR7 gene in patients with chronic hepatitis C in general and in gender distribution. To achieve this goal the study using the methods of "case-control", which included 125 patients with chronic hepatitis C who were treated in the Poltava Regional Clinical Hospital of Infectious Diseases. The group of population control for the study of the prevalence of polymorphisms Asp299Gly TLR4 gene included 90 healthy residents of the Poltava region, for Gln11Leu gene TLR7 - 85.