Publications by authors named "G Driessen"
Background: Evidence on ustekinumab safety in pregnancy is gradually expanding, but its clearance in the postnatal period is unknown. The aim of this study was to investigate ustekinumab concentrations in umbilical cord blood and rates of clearance after birth, as well as how these correlate with maternal drug concentrations, risk of infection, and developmental milestones during the first year of life.
Methods: Pregnant women with inflammatory bowel disease were prospectively recruited from 19 hospitals in Denmark and the Netherlands between 2018 and 2022.
Article Synopsis
- The study aimed to validate an anti-TNFα clearance model to inform the timing of live vaccinations in infants who were exposed to these drugs during pregnancy.
- By analyzing data from newborns and using Bayesian optimization, the model accurately predicted drug concentrations in the PETIT cohort.
- Results showed that the model had high predictive accuracy, with 94% of adalimumab and 93% of infliximab levels falling within the expected range, thus providing reliable guidance for clinicians on vaccination timing.
Purpose: Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) regulates cell growth in response to nutritional status. Central to the mTORC1 function is the Rag-GTPase heterodimer. One component of the Rag heterodimer is RagC (Ras-related GTP-binding protein C), which is encoded by the RRAGC gene.
View Article and Find Full Text PDFBackground: The imposition of lockdowns during the severe acute respiratory syndrome coronavirus-2 pandemic led to a significant decrease in pediatric care utilization in 2020. After restrictions were loosened, a surge in pediatric respiratory disease was observed in pediatric wards. The aim of this study was to quantify the effect of the lockdown(s) on the incidence of pediatric respiratory disease.
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