Publications by authors named "G Dougan"
The use of monoclonal antibodies for the control of drug resistant nosocomial bacteria may alleviate a reliance on broad spectrum antimicrobials for treatment of infection. We identify monoclonal antibodies that may prevent infection caused by carbapenem resistant Acinetobacter baumannii. We use human immune repertoire mice (Kymouse platform mice) as a surrogate for human B cell interrogation to establish an unbiased strategy to probe the antibody-accessible target landscape of clinically relevant A.
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- Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi A, poses a significant public health issue due to rising antimicrobial resistance, complicating treatment options and worsening health outcomes.
- *The study sequenced bacteria samples from blood cultures of febrile patients in urban sites of Dhaka (Bangladesh), Kathmandu (Nepal), and Blantyre (Malawi) to analyze their genetic characteristics and resistance mechanisms.
- *Findings revealed that different genotypes of S. Typhi were present across the sites, with high rates of multidrug resistance in Blantyre and Dhaka but not in Kathmandu, highlighting diverse transmission dynamics and resistance patterns.
We used phage display, antibody engineering, and high-throughput assays to identify antibody-accessible targets of . We report the discovery of monoclonal antibodies (mAbs) binding to type 3 fimbrial proteins, including MrkA. We found that anti-MrkA mAbs were cross-reactive to a diverse panel of clinical isolates, representing different O-serotypes.
View Article and Find Full Text PDFAntimicrobial resistance (AMR) is a growing public health crisis that requires innovative solutions. Current susceptibility testing approaches limit our ability to rapidly distinguish between antimicrobial-susceptible and -resistant organisms. Salmonella Typhimurium (S.
View Article and Find Full Text PDFBackground: Typhoid Fever remains a major cause of morbidity and mortality in low-income settings. The Severe Typhoid in Africa programme was designed to address regional gaps in typhoid burden data and identify populations eligible for interventions using novel typhoid conjugate vaccines.
Methods: A hybrid design, hospital-based prospective surveillance with population-based health-care utilisation surveys, was implemented in six countries in sub-Saharan Africa.