Publications by authors named "G Doug Myers"
Introduction: Pediatric neurology provides care for children with complex developmental disorders with environmental, genetic, metabolic, and teratogenic etiologies. Common neurodevelopmental conditions include attention-deficit hyperactivity disorder (ADHD), and autism spectrum disorder. However, only minimal attention from pediatric neurology journals has been devoted to fetal alcohol spectrum disorder.
View Article and Find Full Text PDFAge prediction based on single cell RNA-Sequencing data (scRNA-Seq) can provide information for patients' susceptibility to various diseases and conditions. In addition, such analysis can be used to identify aging related genes and pathways. To enable age prediction based on scRNA-Seq data, we developed PolyEN, a new regression model which learns continuous representation for expression over time.
View Article and Find Full Text PDFObjectives: To study the population structure and genomic characteristics, including antimicrobial resistance genes, plasmid types and surface polysaccharide type, of the globally distributed Acinetobacter baumannii belonging to ST32 (Institut Pasteur scheme).
Methods: Antibiotic resistance phenotype for 19 antibiotics was determined using Vitek 2. Whole-genome sequencing was performed using the Illumina MiSeq platform.
Comparing rates of agreement between different diagnostic criteria for fetal alcohol spectrum disorder: A systematic review.
Alcohol Clin Exp Res (Hoboken)
November 2024
Article Synopsis
- Diagnostic accuracy in diagnosing Fetal Alcohol Spectrum Disorder (FASD) is under-researched, particularly in comparing different diagnostic criteria.
- A systematic review identified six studies examining agreement rates between eight different FASD diagnostic criteria, revealing a range of agreement from 53.7% to 91% for individual children and 59.4% to 89.5% overall.
- The study highlights significant variations in diagnostic outcomes and stresses the need for large-scale research to understand these discrepancies and their impact on clinical care.
Thrombopoietin (TPO) is a plasma glycoprotein that binds its receptor on megakaryocytes (MKs) and MK progenitors, resulting in enhanced platelet production. The mechanism by which TPO is secreted from hepatocytes remains poorly understood. Lectin mannose-binding 1 (LMAN1) and multiple coagulation factor deficiency 2 (MCFD2) form a complex at the endoplasmic reticulum membrane, recruiting cargo proteins into COPII vesicles for secretion.
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