Publications by authors named "G Dolo"
Cervical cancer (CC) remains a real public health problem in low- and middle-income countries, where technical resources and competent personnel are insufficient. Persistent cervix infection by high-risk human papillomavirus (Hr-HPV) is the main cause of CC development. In the current study, we examined the distribution of Hr-HPV in the general healthy Malian population using cervicovaginal self- sampling.
View Article and Find Full Text PDFIntroduction: Long-term exposure to high-risk human papillomavirus (Hr-HPV) is a well-known necessary condition for development of cervical cancer. The aim of this study is to screen for Hr-HPV using vaginal self-sampling, which is a more effective approach to improve women's adherence and increase screening rates.
Methods: This pilot study included a total of 100 Women living with HIV (WLWHIV), recruited from the Center for Listening, Care, Animation, and Counseling of People Living with HIV in Bamako.
Article Synopsis
- The MTHFR gene is important for processing folates and homocysteine, which can impact gene expression and potentially lead to breast cancer development; mutations in this gene may affect levels of certain compounds involved in protein synthesis and methylation.* -
- A study was conducted using the PCR-RFLP technique on 127 breast cancer patients and 160 healthy controls in Mali to analyze the genotypic profiles related to MTHFR mutations, revealing similar distributions of genotypes in both groups.* -
- The research found no significant association between MTHFR gene polymorphisms and breast cancer risk among the Malian population, indicating that these genetic variations did not influence the likelihood of developing the disease.*
A literature review showed some discrepancies regarding the association of with the risk of cervical cancer. To allow more precise analysis of the data by increasing the number of cases studied and more acceptable generalization by considering results from different sources, the present meta-analysis was performed on available published studies that explored the relationship between SNP of the gene and the risk of cervical cancer. Eleven available studies, including 4187 cases and 3311 controls, were included in this study investigating the relationship between the polymorphism of and cervical cancer risk.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate how genetic variations (polymorphisms) in CYP2B6 and CYP3A4 affect the health responses of HIV-positive patients, focusing on their viral load and immune system functioning.
- A total of 153 patients were involved, and assessments were made on their viral loads and CD4 T cell counts at the start and after six months, utilizing TaqMan genotyping assays to identify genetic markers.
- Results indicated that certain genetic variations, particularly in CYP2B6, correlate with viral load suppression and increases in CD4 cell counts, suggesting these genetic markers could help predict treatment outcomes in HIV patients.