Publications by authors named "G Dobson"
Article Synopsis
- - Severe traumatic brain injury (TBI) has a high mortality rate of about 25-30%, and despite extensive research, effective drug therapies have not yet emerged due to factors like relying on specific-pathogen free (SPF) animals and a narrow focus in drug design.
- - The progression of TBI involves a cascade of damaging processes such as ischemia, inflammation, and immune dysfunction, which lead to further complications and reduced outcomes for patients.
- - Researchers propose that early intervention to correct sympathetic hyperactivity and immune activation can improve recovery, and they are developing a fluid therapy (adenosine, lidocaine, and magnesium) that has shown promise in minimizing secondary injury and supporting cardiovascular function in TBI cases. *
The main problem of vascular preservation is the maintenance of vessel graft quality and function following extended storage. Conventional preservation solutions such as histidine-tryptophan-ketoglutarate (HTK) solution, Phosphate-Buffer Solution (PBS), or sodium chloride 0.9% has been shown to be inadequate in preserving vascular physiological function after 3 days of cold storage.
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- Non-compressible torso hemorrhagic (NCTH) shock is a leading cause of death in battlefield trauma, making the development of new resuscitation therapies essential, especially focusing on drugs like adenosine, lidocaine, and magnesium (ALM).
- A literature review explored the effects of permissive hypotension, while a preclinical study on female pigs examined the efficacy of a fluid resuscitation protocol involving 3% NaCl with or without ALM.
- Results indicated that achieving a mean arterial pressure (MAP) of about 50 mmHg could either be beneficial or harmful, depending on cardiac output and systemic vascular resistance, with ALM therapy improving oxygen delivery and survival rates by enhancing heart function and reducing internal bleeding.
For decades, left ventricular ejection fraction (LVEF < 35%) has been a mainstay for identifying heart failure (HF) patients most likely to benefit from an implantable cardioverter defibrillator (ICD). However, LVEF is a poor predictor of sudden cardiac death (SCD) and ignores 50% of HF patients with mildly reduced and preserved LVEF. The current international guidelines for primary prophylaxis ICD therapy are inadequate.
View Article and Find Full Text PDFSpontaneous regression (SR) of chronic lymphocytic leukemia (CLL) is a rare event (0.2% - 1%). Some advances have been made in understanding the tumor genetic characteristics of such patients, although the immunological mechanisms leading to SR remain unclear.
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