Morphological, histochemical and histoenzymatic investigations on the lungs of mice chronically infected with influenza virus type A.

The lungs of mice having survived three inoculations with influenza virus A/PR8/34 (H1N1) repeated at 7-day intervals (an experimentally induced "chronic" influenza infection) were subjected to histological, electron optic, histochemical and histoenzymatic investigations. Hyperemia, edema and infiltration of the alveolar walls with lymphoid and monocytic elements could be observed. Electron microscopy revealed changes at the level of different ultrastructures of both lung and infiltration cells.

Ultrastructural peculiarities of intercellular junctions in bronchopulmonary carcinomas.

Six bronchopulmonary carcinomas of various histological types (macrocellular, epidermoid) were electronmicroscopically studied on bronchial biopsy samples. The scarcity of intercellular junctions was observed in all of them, especially in carcinoma types or zones (i.e.

Persistent measles virus infection in a calf kidney cell line. Note III. Cellular alterations in the selected chronically infected K-2 cell line.

Marked morphological, growth and chromosome alterations pointing to in vitro cellular transformation were made evident in a selected calf kidney cell line (K-2) chronically infected with measles virus. The transformed cell line released infectant virus and had no oncogenic potential for the hamster.