Publications by authors named "G Di Dalmazi"
Article Synopsis
- Filamin A (FLNA) is found at lower levels in adrenocortical carcinomas (ACC) compared to adenomas (ACA), and its presence is linked to less aggressive tumor behavior due to its role in regulating IGF1R signaling.
- The study investigated the expression of Wee1 kinase in ACC and how it is influenced by FLNA, revealing increased Wee1 and decreased FLNA proteins in ACC, along with insights into the effects of the Wee1 inhibitor AZD1775.
- Findings indicate that FLNA promotes the degradation of Wee1, and that low FLNA levels in ACC lead to heightened Wee1, suggesting that targeting Wee1 with inhibitors could be a promising treatment strategy for FLNA-deficient
Quercetin is the most abundant flavonoid present in fruits and vegetables. For its antiproliferative, antiviral, anti-inflammatory and antioxidants activities, it is an active ingredient of several herbal remedies and is available as a nutraceutical. Experimental studies performed in vitro have demonstrated that quercetin inhibits growth and function in normal thyroid cells and may act as a thyroid disruptor.
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- Adrenal incidentalomas (AIs) and pituitary incidentalomas (PIs) are common findings due to increased imaging, with this review focusing on the prevalence of hypercortisolism in these patients.
- The study used PubMed to analyze demographic data and diagnostic accuracy regarding hypercortisolism and found significant links between mild autonomous cortisol secretion (MACS), cardiometabolic risks, and higher mortality.
- Early detection and management of hypercortisolism are crucial to prevent complications, highlighting the need for targeted screening in high-risk individuals.
Brain metastasis mimicking a cavernous angioma as initial presentation of papillary thyroid carcinoma.
Endocrinol Diabetes Metab Case Rep
July 2024
Summary: Brain metastases as the first clinical presentation of a papillary thyroid carcinoma (PTC) are exceptional, while cavernous angiomas are common cerebral malformations. We report the case of a 36-year-old male with an incidental brain lesion mimicking a cavernous angioma on MRI. Gamma knife radiosurgery was performed, but after 6 months, the patient developed neurological symptoms, and a repeat brain MRI revealed a significant increase in the mass.
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