Publications by authors named "G Demyashkin"
Article Synopsis
- Kidney disease is becoming a major global health concern, with projections indicating it will rank as the fifth-leading cause of life lost by 2040.
- The research focuses on understanding the dose-dependent effects of electron irradiation on renal tissue, as the impact of this type of radiation is not well studied compared to others like gamma and X-rays.
- Findings show that higher doses of electron irradiation cause increased oxidative stress, inflammation, and significant damage to kidney tissue, including apoptosis and early fibrosis, highlighting the importance of managing radiation doses to protect kidney function.
In this study, the optimal engraving parameters were determined through the analysis of scanning electron microscopy (SEM) data, as follows: a laser power density of 5.5 × 10 W/cm, an irradiation rate of 0.1 mm/s, a well radius of 60 μm, a distance between well centers of 200 μm, and a number of passes for each well of 20.
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- - Radiation-induced liver disease (RILD) is a serious side effect of radiotherapy used for abdominal cancers, particularly affecting the liver's crucial functions and limiting the overall effectiveness of treatment.
- - Electron beam therapy has shown promise in targeting tumors with less damage to surrounding healthy tissue, but the long-term effects on liver health and the potential for chronic damage need further research, especially regarding vitamin C's protective qualities.
- - A study involving male Wistar rats examined the impact of electron beam radiation and vitamin C on liver health, showing that radiation caused weight loss and liver mass reduction, while various biochemical and genetic analyses provided insights into how vitamin C might mitigate some of these adverse effects.
Radiotherapy is one of the risk factors for radiation-induced premature ovarian failure and infertility in cancer patients. The development of methods for ovarian radioprotection remains relevant. Moreover, electrons are a little-studied and promising method of radiation with the least toxic effect on normal tissues.
View Article and Find Full Text PDFPreviously, we showed the antitumor activity of the new NOS/PDK inhibitor T1084 (1-isobutanoyl-2-isopropylisothiourea dichloroacetate). The present study included an assessment of in vitro cytotoxicity against human malignant and normal cells according to the MTT-test and in vivo antitumor effects in solid tumor models in comparison with precursor compounds T1023 (NOS inhibitor; 1-isobutanoyl-2-isopropylisothiourea hydrobromide) and Na-DCA (PDK inhibitor; sodium dichloroacetate), using morphological, histological, and immunohistochemical methods. The effects of T1084 and T1023 on the in vitro survival of normal (MRC-5) and most malignant cells (A375, MFC-7, K562, OAW42, and PC-3) were similar and quantitatively equal.
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