Publications by authors named "G Deliconstantinos"
Article Synopsis
- Acute Myeloid Leukemia (AML) is a serious illness that often needs strong treatments called chemotherapy, but sometimes these treatments don't work well enough.
- Researchers studied how certain genes related to DNA damage respond in AML cells after chemotherapy using two different medicines: Idarubicin and Cytarabine.
- They found that a gene called PPP1R15A is important for helping cells recover from stress, and when they turned off this gene, the cancer cells didn't survive as well when treated with the chemotherapy, suggesting a way to make the treatment more effective.
Background/aim: The DSL proteins, Serrate and Delta, which act as Notch receptor ligands, mediate signalling between adjacent cells, when a ligand-expressing cell binds to Notch on an adjacent receiving cell. Notch is ubiquitously expressed and DSL protein mis-expression can have devastating developmental consequences. Although transcriptional regulation of Delta and Serrate has been amply documented, we examined whether they are also regulated at the level of translation.
View Article and Find Full Text PDFBackground/aim: Cigarette smoke (CS) is a major environmental health threat. The oxidative stress induced by CS on keratinocytes and the possible protective effect of nicotine, its receptor inhibitors, and Pinus halepensis bark extract in relation to known antioxidants were investigated.
Materials And Methods: Primary mouse keratinocytes were exposed to cigarette smoke in the presence and absence of Pinus halepensis bark extract (1 μg/ml), rutin (50 μM) and ascorbic acid (250 μM), nicotine (1 μM) with or without mecamylamine (5 μM) and α-bungarotoxin (0.
Background/aim: The tachykinin mouse hemokinin-1, expressed by the mouse Tac4 gene, produces either analgesia or nociception, interacting with the neurokinin 1 receptor. TAC4 precursor processing is not identical to the processing of the TAC1 precursor, for the release of substance P (amidated undecapeptide). The characterization of the mouse hemokinin-1 sequence was required.
View Article and Find Full Text PDFPrevious studies have shown that alpha1-adrenergic receptor antagonists may alter seminal vesicle contractility and impair fertility in male rats. This study was designed to investigate the effects of terazosin on the catalase expression in the seminal vesicles and the lipid peroxidation of the seminal fluid in normal adult rats. Wistar rats were treated with terazosin (1.
View Article and Find Full Text PDF