Fighting against self-stigma in adults with self-reported diagnosis of OCD: A single-arm pilot study using a mobile app-based intervention.

Background: Obsessive-compulsive disorder (OCD) is a disabling disorder, and self-stigma negatively impacts quality of life, symptom severity and self-esteem. esTOCma is a smartphone-based serious game developed to increase knowledge about OCD and reduce stigma. It features 10 missions using psychoeducation, indirect contact and cognitive restructuring.

Flexibility, Resistance, Aerobic, Movement Execution (FRAME) training program to improve gait capacity in adults with Hereditary Spastic Paraplegia: protocol for a single-cohort feasibility trial.

Background: Hereditary Spastic Paraplegia (HSP) is a heterogeneous group of inherited neurological disorders characterized by progressive weakness and spasticity in the lower limbs, significantly affecting gait capacity (endurance and speed). Although specific interventions have been already investigated, there is currently a lack of comprehensive, structured neurorehabilitation programs to improve gait capacity in adults with HSP. Thus, this protocol aims to explore the feasibility and effectiveness of a composite training targeting flexibility, muscle strength, motor control, balance, and aerobic capacity.

Pharmacological therapy for relieving pain in panretinal photocoagulation: A network meta-analysis of randomized controlled trials.

A Bayesian network meta-analysis (NMA) can help compare the various types of analgesics and anesthetics used for lowering pain of panretinal photocoagulation. We carried out a systematic review and network meta-analysis to assess pharmacological interventions for relieving pain in patients undergoing panretinal photocoagulation (PRP). We included 15 randomized controlled trials and 4 crossover trials with a total of 1787 eyes and 45.

Tactile edges and motion via patterned microstimulation of the human somatosensory cortex.

Intracortical microstimulation (ICMS) of somatosensory cortex evokes tactile sensations whose properties can be systematically manipulated by varying stimulation parameters. However, ICMS currently provides an imperfect sense of touch, limiting manual dexterity and tactile experience. Leveraging our understanding of how tactile features are encoded in the primary somatosensory cortex (S1), we sought to inform individuals with paralysis about local geometry and apparent motion of objects on their skin.

Evaluation of the Effects of Autologous Leukocyte- and Platelet-Rich Fibrin Membranes for Treating Chronic Wounds: A Prospective Study.

(1) Background: The aim of this prospective study was to evaluate the efficacy of topical application of leukocyte- and platelet-rich fibrin (L-PRF) membranes for treating chronic cutaneous wounds in dogs. (2) Methods: Chronic wounds unresponsive to conventional treatments were assessed on digital photographs and classified using the Bates-Jensen Wound Assessment Tool (BWAT). Each lesion was treated with L-PRF membranes.