Publications by authors named "G Dean"
Altered mechanotransduction has been proposed as a putative mechanism for disease pathophysiology, yet evidence remains scarce. Here we introduce a concept we call single cell immuno-mechanical modulation, which links immunology, integrin biology, cellular mechanics, and disease pathophysiology and symptomology. Using a micropatterned hydrogel-laden coverslip compatible with standard fluorescence microscopy, we conduct a clinical mechanobiology study, specifically focusing on immune thrombocytopenia (ITP), an autoantibody-mediated platelet disorder that currently lacks a reliable biomarker for bleeding risk.
View Article and Find Full Text PDFIntroduction: In line with the NHS net zero initiative, University Hospitals Sussex (UHS) committed to a Green Plan which included the introduction of reusable instruments. Following positive responses from a staff and patient survey in 2021, the sexual health and contraception (SHAC) department began a pilot scheme of 100 medium size reusable stainless steel vaginal specula (RMS) as an alternative to disposable acrylic models. The aim was to determine outcomes regarding sustainability goals and clinician experiences.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how radiology staff perceives an AI tool designed to expedite lung cancer detection in chest X-rays, surveying staff before and after its implementation.
- Initial expectations of the AI being time-saving shifted post-implementation to focus on faster patient follow-ups and a recognition of benefits despite integration challenges.
- Ongoing staff feedback and support are crucial for a smooth AI integration in clinical settings, fostering a positive adaptation towards its usage in patient care.