Central serous chorioretinopathy associated with administration of sympathomimetic agents.

Purpose: To report central serous chorioretinopathy associated with excessive use of compounds with sympathomimetic activity.

Design: Observational case series.

Methods: Four patients presented with clinical and fluorescein angiographic evidence of central serous chorioretinopathy.

Immunocytochemical features of retinoblastoma in an adult.

Objective: To describe the clinical course and immunocytochemical characteristics of an unusual intraocular tumor.

Methods: Immunocytochemical analysis of the enucleated eye with an intraocular mass that markedly waxed and waned in size during 1 year of close observation of a 29-year-old woman.

Results: Most of the tumor was composed of either dying or rapidly proliferating cells.

Retinal trypsin digest study of cystoid macular edema associated with peripheral choroidal melanoma.

Purpose: Although the association of cystoid macular edema with peripheral choroidal melanoma has been studied previously, the pathogenesis of cystoid macular edema as evaluated by light and electron microscopy remains controversial. We evaluated the cause of cystoid macular edema at the retinal capillary level.

Methods: We clinicopathologically correlated petaloidlike changes noted on fluorescein angiography with the corresponding morphologic changes, as documented by retinal trypsin digest preparation.

Macular heterotopia in proliferative diabetic retinopathy.

Macular heterotopia secondary to proliferative diabetic retinopathy has been previously reported in clinical cases. To our knowledge, we present the first clinicopathologic case of macular heterotopia in a young patient with proliferative diabetic retinopathy. The significant pathologic findings included dense fibrovascular tissue on the disc to correspond with nasal tractional retinal detachment, a superonasally displaced fovea, and an area of stripped and recoiled internal limiting membrane overlying a retinal fold.