Publications by authors named "G Davey-Smith"
Breastfeeding is hypothesised to benefit child health and cognitive functioning by providing long-chain polyunsaturated fatty acids, which are essential for brain development. In 2007, Caspi et al. found evidence in two cohorts for an interaction between genetic variation in the FADS2 gene (a gene involved in fatty acid metabolism) and breastfeeding on IQ.
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- The study explores the link between hip shape and the risk of hip osteoarthritis and fractures, using data from large cohorts to analyze genetic factors influencing hip shape.
- Researchers identified numerous genetic signals related to hip shape but found no causal effect of hip shape on osteoarthritis, while certain hip shapes were linked to a higher risk of hip fractures.
- The findings suggest that focusing on hip shape might not be an effective strategy for preventing osteoarthritis in older adults, despite its association with hip fractures.
The prevalence of type 2 diabetes (T2D) varies among populations of different races/ethnicities. The influence of genetically proxied LDL cholesterol lowering through proprotein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) on T2D in non-European populations is not well established. A drug target Mendelian randomization approach was used to assess the effects of PCSK9 and HMGCR inhibition on T2D risk and glycemic traits in five populations: East Asian (EAS), South Asian (SAS), Hispanic (HISP), African (AFR), and Europe (EUR).
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