Publications by authors named "G Daniels"

Introduction: Racial and ethnic disparities in the presentation and outcomes of lung cancer are widely known. To evaluate potential factors contributing to these observations, we measured systemic immune parameters in Black and White patients with lung cancer.

Methods: Patients scheduled to receive cancer immunotherapy were enrolled in a multi-institutional prospective biospecimen collection registry.

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Background: Black/African Americans experience a disproportionate cancer burden and mortality rates. Racial/ethnic variation in cancer burden reflects systemic and healthcare inequities, cancer risk factors, and heredity and genomic diversity. Multiple systemic, socio-cultural, economic, and individual factors also contribute to disproportionately low Black/African American participation in cancer clinical trials.

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Article Synopsis
  • Combination immune checkpoint blockade targeting PD-1 and CTLA-4 shows lower efficacy in acral lentiginous melanoma (ALM) compared to cutaneous melanoma (CM), with an objective response rate of only 18.3%.
  • In a study of 109 patients, most had advanced cancer (stage IV), with median progression-free survival of 4.2 months and overall survival of 17 months.
  • Significant treatment-related adverse events were common, indicating similar toxicity levels, but specific demographic factors like Asian ethnicity were linked to worse overall survival, highlighting the need for new treatment strategies for ALM.
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The Deep South is the epicenter of the HIV-epidemic in the United States, with rural AAs bearing the greatest burden. Traditional efforts to improve testing efforts have been largely unsuccessful due to their failure to recognize and leverage the sociopolitical and cultural factors that affect the uptake of HIV-screening interventions at the community level. The purpose of this study was to gain a deeper understanding of the socio-cultural contexts impacting HIV-testing in the rural South, and to assess strategies to increase testing in rural, Southern communities.

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