Publications by authors named "G Daccache"
Background: Whether the optimization of cerebral oxygenation based on regional cerebral oxygen saturation (rSO) monitoring reduces the occurrence of cerebral ischemic lesions is unknown.
Methods: This multicenter, randomized, controlled trial recruited adults admitted for scheduled carotid endarterectomy. Patients were randomized between the standard of care or optimization of cerebral oxygenation based on rSO monitoring using near-infrared spectroscopy.
Article Synopsis
- The study investigated how variations in the CYP2D6 gene affect the body’s response to tramadol and its active form, O-dT, in European adult patients after surgery.
- Researchers classified participants' CYP2D6 metabolizer types (EM, IM, PM, UM) and measured the O-dT/T ratio in their plasma to see if it could effectively indicate their CYP2D6 phenotype.
- Results showed that while the O-dT/T ratio was lower in poor metabolizers (PM) compared to non-PM, there was significant overlap between groups, indicating that tramadol is not a reliable drug for accurately determining CYP2D6 phenotypes.
Background: The present trial was designed to assess whether individualized strategies of fluid administration using a noninvasive plethysmographic variability index could reduce the postoperative hospital length of stay and morbidity after intermediate-risk surgery.
Methods: This was a multicenter, randomized, nonblinded parallel-group clinical trial conducted in five hospitals. Adult patients in sinus rhythm having elective orthopedic surgery (knee or hip arthroplasty) under general anesthesia were enrolled.
Background: Polyamines have been identified as pain agonists and interact with N-methyl-D-aspartate receptors. A prospective, randomized, multicenter, and blinded phase II clinical trial was conducted to evaluate a polyamine-deficient diet for the treatment of perioperative pain in patients during spinal surgery.
Methods: All analyses followed the intention-to-treat principle.