Public Health.

Background: The BetterBrains Trial is a prospective behavior-modification blinded endpoint randomized controlled trial to delay cognitive decline in middle-aged adults (aged 40-70) with a family history of dementia. The primary outcome is absence of decline on at-least one out of four cognitive tests at 24-months. We present trial recruitment and current participant completion statistics and baseline demographic, modifiable dementia risk factor (MDRF) and cognitive characteristics of the randomized sample, blinded to intervention arm.

Efficacy of Amitriptyline in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.

Background/aims: Amitriptyline is prescribed off-label for irritable bowel syndrome (IBS). We conducted a meta-analysis to assess its efficacy.

Methods: A systematic literature review was conducted until November 10, 2023, using MEDLINE, Embase, Cochrane Library, and Web of Science to study the efficacy of amitriptyline in patients with IBS.

Cellular and biochemical alterations induced by diesel oil in the brown algaSargassum cymosumvar.stenophyllumcultured in vitro.

The effect of the in vitro acute exposure to diesel oil (0.001%, 0.01%, 0.

First Identification of Emerging Pathogenic Yeast in (Diptera: Psychodidae) at a Brazilian Hospital.

Psychodinae (Diptera: Psychodidae), commonly known as "drain flies", are a subfamily of insects adapted to environments modified by humans. While often regarded as harmless, it has been reported that they may carry pathogenic microorganisms, contributing to hospital environmental contamination and potentially playing a role in healthcare-associated infections. This study aimed to investigate drain flies in a hospital setting to assess their role in carrying microbial pathogens.

Stilbenes in Red Wine: Formation and Biological Potential of Resveratrol and Piceid Dimers.

Resveratrol and its glucoside, piceid, are the primary stilbenes present in wine. These compounds are well known for their pharmaceutical properties. However, these compounds can undergo chemical transformations in wines, such as polymerization in the presence of metallic reagents.