Publications by authors named "G DE VOS"
Keratan sulfate (KS) is a highly complex proteoglycan that has a poly-LacNAc chain that can be modified by diverse patterns of sulfate esters at C-6 positions of galactoside (Gal) and -acetylglucosamine (GlcNAc) residues. Here, a chemo-enzymatic methodology is described that can control the pattern of sulfation at Gal using UDP-Gal-aldehyde as a donor for poly-LacNAc assembly to temporarily block specific sites from sulfation by galactose 6-sulfotransferase (CHST1).
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- Schizophrenia, schizoaffective disorder, and bipolar disorder are serious mental illnesses associated with emotional, cognitive, and behavioral issues, leading to major health problems and reduced life expectancy.
- The study aims to test the effectiveness of a modified ketogenic diet over 14 weeks for improving symptoms in patients with these disorders, compared to a standard healthy eating diet.
- Key outcomes will focus on changes in psychiatric symptoms and cognitive function, as well as metabolic health measures.
-glycosylation is a common post-translational modification that is essential for the defensive properties of mucus barriers. Incomplete and altered -glycosylation is often linked to severe diseases, such as cancer, cystic fibrosis, and chronic obstructive pulmonary disease. Originating from a nontemplate-driven biosynthesis, mucin-type -glycan structures are very complex.
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- Mucins' O-glycosylation is crucial for mucus defense but abnormal glycosylation is linked to diseases like COPD, cancer, and Crohn's.
- Analyzing these complex O-glycans poses challenges due to their varied structures and the need for advanced techniques like LC-MS, which can be slow and inconsistent.
- A new method using trapped ion mobility mass spectrometry offers a faster and more reliable way to separate and identify O-glycans, significantly reducing analysis time and successfully mapping O-glycosylation in cystic fibrosis sputum samples.