[Action of antioxidants on membrane-toxic effects of anticholinesterase agents].

It was found therapeutic-preventive effectiveness of antioxidants (1,4-dihydropyridine derivatives) at poisoning with malathion insecticide. The effect of 1,4-dihydropyridine derivatives can be attributed to a prevention of lipid peroxidation. Antioxidants do not affect the toxicity of 0,0-dimethyl-0-2,2-dichlorvinylphosphate.

[Effects of nifedipine and riodipine on biochemical processes in intact erythrocytes].

Cardiovascular drugs nifedipine and riodipine (1,4-dihydropyridine derivatives) were studied as to their effect on some biochemical characteristics of erythrocytes. Both compounds failed to effect 2,3-diphosphoglycerate concentration in intact erythrocytes, but slightly decreased the level of adenosinetriphosphate. The drugs inhibited the process of acid hemolysis, this inhibition being particularly manifest in the case of nifedipine.