Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions.

Microsomal fractions isolated from rat anterior pituitary glands catalyze the oxygenation of arachidonic acid. By a combination of chromatographic and mass spectrometric techniques, we have identified epoxyeicosatrienoic acids as reaction products and thus documented the presence of an NADPH-dependent arachidonic acid epoxygenase activity in rat adenohypophysis.