Publications by authors named "G D Montoya"
Nicotinamide adenine dinucleotide (NAD) is an essential metabolite, and its depletion serves as a common bacterial immune strategy against bacteriophages (phages). In a recent issue of Nature, Osterman et al. reveal two phage-encoded NAD restoration pathways, showcasing the phages' innovative counterstrategies against bacterial immunity and providing insights for developing novel antimicrobial approaches.
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- Cannabis sativa is a versatile plant with many therapeutic benefits, and scientists want to study its different types to help create better treatments for people.
- A study in Colombia looked at 156 cannabis plants and found a lot of differences in the compounds they produce, especially in various climates.
- The research shows that Colombia could be an important place for growing cannabis with unique qualities, which could help in both medicine and recreational use around the world.
Article Synopsis
- The study investigates how the protein Mrc1 in fission yeast plays a crucial role in the inheritance of histones during DNA replication, which is essential for maintaining epigenetic memory.
- It reveals that mutations in Mrc1 can disrupt the proper segregation of parental histones to the lagging strand, leading to loss of gene silencing.
- The research proposes that Mrc1 is involved in controlling histone recycling between leading and lagging strands, ensuring that both daughter cells receive the necessary epigenetic information.
CRISPR-associated transposons (CASTs) are mobile genetic elements that co-opt CRISPR-Cas systems for RNA-guided DNA transposition. CASTs integrate large DNA cargos into the attachment (att) site independently of homology-directed repair and thus hold promise for eukaryotic genome engineering. However, the functional diversity and complexity of CASTs hinder an understanding of their mechanisms.
View Article and Find Full Text PDFRetrons are toxin-antitoxin systems protecting bacteria against bacteriophages via abortive infection. The Retron-Eco1 antitoxin is formed by a reverse transcriptase (RT) and a non-coding RNA (ncRNA)/multi-copy single-stranded DNA (msDNA) hybrid that neutralizes an uncharacterized toxic effector. Yet, the molecular mechanisms underlying phage defense remain unknown.
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