Publications by authors named "G D Maclaine"
Spinal muscular atrophy (SMA) is a rare, genetic neurodegenerative disorder caused by insufficient production of survival motor neuron (SMN) protein. Diminished SMN protein levels lead to motor neuron loss, causing muscle atrophy and weakness that impairs daily functioning and reduces quality of life. SMN upregulators offer clinical improvements and increased survival in SMA patients, although significant unmet needs remain.
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- Traditional assessment of movement quality in patients with spinocerebellar ataxia relies on subjective scales, making it difficult to detect subtle mobility changes; hence, researchers explored using machine learning to enhance assessment.
- The study involved a phase 3 trial comparing the effects of the drug troriluzole versus a placebo on gait quality, measured through video analysis and a new stability metric called the Pose Dispersion Index.
- Results showed that those taking troriluzole had significant improvements in the tandem walk stability measure after 48 weeks, while a trend in natural walking improvement was also noted, and lower scores in baseline stability were linked to a higher fall risk.
This study aimed to explore the impact of caring for an individual with neurogenic orthostatic hypotension (nOH). Informal caregivers of individuals with nOH and either Parkinson's disease, multiple system atrophy, pure autonomic failure or dementia with Lewy bodies completed semi-structured interviews. Data were analyzed using thematic analysis; the identified concepts were used to develop a conceptual model.
View Article and Find Full Text PDFThis study explores the burden of caring for an individual with neurogenic orthostatic hypotension (nOH) and an underlying neurodegenerative disease (Parkinson's disease, multiple system atrophy, pure autonomic failure or dementia with Lewy bodies). A survey including several validated instruments was conducted with informal caregivers of individuals with Parkinson's disease, multiple system atrophy, pure autonomic failure or dementia with Lewy bodies. Caregivers of patients with nOH (n = 60) reported greater burden across all outcomes compared with those without nOH (n = 60).
View Article and Find Full Text PDFIntroduction: There is a lack of quantitative data on healthcare professionals' (HCPs) time dedicated to nebulized chronic obstructive pulmonary disease (COPD) therapy in inpatient and long-term care (LTC) settings. Using time and motion methodology, we quantified HCP time and opportunity costs (time and materials) associated with nebulized COPD therapy in inpatient and LTC settings and estimated efficiencies of changing to once-daily therapy.
Methods: A case report form was built to reflect local nebulization workflow.