Repurposing of Rutan showed effective treatment for COVID-19 disease.

Unlabelled: Previously, from the tannic sumac plant (), we developed the Rutan 25 mg oral drug tablets with antiviral activity against influenza A and B viruses, adenoviruses, paramyxoviruses, herpes virus, and cytomegalovirus. Here, our re-purposing study demonstrated that Rutan at 25, 50, and 100 mg/kg provided a very effective and safe treatment for COVID-19 infection, simultaneously inhibiting two vital enzyme systems of the SARS-CoV-2 virus: 3C-like proteinase (3CLpro) and RNA-dependent RNA polymerase (RdRp). There was no drug accumulation in experimental animals' organs and tissues.

Antimicrobial resistance patterns and prevalence of class 1 and 2 integrons in Shigella flexneri and Shigella sonnei isolated in Uzbekistan.

Background: Shigella is a frequent cause of bacterial dysentery in the developing world. Treatment with effective antibiotics is recommended for shigellosis, but options become limited due to globally emerging resistance. One of the mechanisms for the development of resistance utilizes integrons.

[Combined use of hydrogen sulfide baths and galvanopeloid therapy with magnetolaser radiation in osteoarthrosis patients at a health resort].

The study included 174 patients with osteoarthrosis (OA) of the first and second x-ray stage, subclinical or mild reactive synovitis. The patients received sanatorium treatment including hydrogen sulphide balneotherapy, galvanopeloid therapy with sulphide muds of Imeretinsk deposit (Sochi) by the segmental-local technique, prior magnetic laser radiation in some cases. Anesthetic, anti-inflammatory effects were found which proved highest in consecutive use of magnetolaser radiation and galvanopeloid therapy as shown by normalization of autonomic function, improvement of peripheral circulation, inhibition of proteolysis due to antioxidant and adaptogenic actions.

[The inhalation use of hydrogen sulfide water in the health resort rehabilitation of osteoarthrosis patients living in areas with radionuclide contamination].

A randomized trial of 77 patients with polyosteoarthrosis of stage I-II was made in two groups which received hydrogen sulfide balneotherapy according to conventional regimen (controls) and inhalations of hydrogen sulfide water. Ultrasonic hydrogen sulfide inhalations are not inferior in efficacy to conventional treatment, but balneoreaction occurred less frequently. High bioavailability of hydrogen sulfide in inhalations provides antiinflammatory, analgetic, trophic effects, stimulates general and immune reactivity of the body.