Publications by authors named "G D Hammond"
Corticosteroid binding globulin (CBG; SERPINA6) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted proteolytic cleavage of CBG by neutrophil elastase (NE; ELANE) significantly reduces CBG binding affinity, potentially increasing 'free' glucocorticoid levels at sites of inflammation. NE is inhibited by alpha-1-antitrypsin (AAT; SERPINA1).
View Article and Find Full Text PDFBackground: The univoltine leaf beetle (Curtis, 1837b) is native to the Palaearctic Region from Japan to western Europe.This species was previously evaluated as a potential biological control agent against invasive populations of the woodland weed (Bieb.) Cavara & Grande (Brassicaceae) in North America, but rejected because it could harm native and at-risk populations of Brassicaceae.
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- - The study investigates how a peptide hormone (PTH) interacts with its receptor (PTHR) and β-arrestin (βarr) to form a ternary complex, which is key for G protein-coupled receptor (GPCR) signaling.
- - Using fluorescent markers and advanced imaging techniques, the research shows that PTHR moves freely in the cell membrane while unbound PTH has limited mobility, indicating a distinct dynamic behavior.
- - The formation of the PTH-PTHR-βarr complex happens in three steps: ligand-receptor collisions, βarr recruitment triggered by a specific lipid (PIP), and final assembly within clathrin clusters, highlighting the importance of PIP in GPCR
Opioid overdose is a leading cause of death in the United States, and engaging with patients following overdose to provide harm reduction and recovery resources can prove difficult. Quick response models use mobile, multidisciplinary teams to establish a time-sensitive connection between individuals who overdosed and harm reduction and recovery resources that improve outcomes. These quick response models are consistent with the broader field of mobile-integrated health programs that are growing in number and acceptability, though the literature base is sparse and programs vary.
View Article and Find Full Text PDFGenetically encoded lipid biosensors are essential cell biological tools. They are the only technique that provide real time, spatially resolved kinetic data for lipid dynamics in living cells. Despite clear strengths, these tools also carry significant drawbacks; most notably, lipid molecules bound to biosensors cannot engage with their effectors, causing inhibition.
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