Publications by authors named "G D Bossart"

Endothelial function declines with aging and independently predicts future cardiovascular disease (CVD) events. Diving also impairs endothelial function in humans. Yet, dolphins, being long-lived mammals adapted to diving, undergo repetitive cycles of tissue hypoxia-reoxygenation and disturbed shear stress without manifesting any apparent detrimental effects, as CVD is essentially nonexistent in these animals.

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Timely detection and understanding of causes for population decline are essential for effective wildlife management and conservation. Assessing trends in population size has been the standard approach, but we propose that monitoring population health could prove more effective. We collated data from 7 bottlenose dolphin (Tursiops truncatus) populations in the southeastern United States to develop a method for estimating survival probability based on a suite of health measures identified by experts as indices for inflammatory, metabolic, pulmonary, and neuroendocrine systems.

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Cumulative exposure to sub-lethal anthropogenic stressors can affect the health and reproduction of coastal cetaceans and hence their population viability. To date, we do not have a clear understanding of the notion of health for cetaceans in an ecological context; that is, how health status affects the ability of individuals to survive and reproduce. Here, we make use of a unique health-monitoring programme of estuarine bottlenose dolphins in South Carolina and Florida to determine de novo changes in biological pathways, using untargeted plasma metabolomics, depending on the health status of individuals obtained from veterinary screening.

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Article Synopsis
  • The study investigated the immunotoxic effects of a 37 PCB congener mixture found in dolphins on adult female BCF mice.
  • Mice were exposed to varying doses of the PCB mixture for 28 days, leading to significant liver weight increases at the highest dose and suppressed IgM antibody production across all treatments.
  • The findings suggest that IgM production is particularly sensitive to PCB exposure, with no observed adverse effect level (NOAEL) identified, and the estimated effective dose for IgM suppression was 2.4 mg/kg/day.
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On March 2, 2005 ~70 rough-toothed dolphins () mass stranded along mud flats and associated canals on the Atlantic Ocean side of Marathon Key, Florida. Forty-six were necropsied and placed into two groups for analysis: Group-1 animals ( = 34; 65%) that died prior to medical intervention and rehabilitative efforts and Group-2 animals ( = 12; 35%) that died in rehabilitation. Thirty-four animals were females (18 adults, 5 juvenile/subadult, 7 calves, and 4 of undetermined age) and 12 were males (6 adults, 4 juvenile/subadults, 1 calf, and 1 of undetermined age).

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