Response of the thymus and spleen of CBA mice with sarcoma 37 on intravenous and subcutaneous administration of syngeneic dendritic cells.

Objective: To compare the effect of intravenous (i/v) and subcutaneous (s/c) infusion of syngeneic dendritic cells (DC) loaded or unloaded with lyzate of tumor cells (LTC) on apoptosis and proliferation of thymic and splenic cells in CBA mice with sarcoma 37 (S 37).

Methods: Experiments were carried out on CBA mice bearing transplanted ascitic form of S 37. DC loaded and unloaded with LTC were infused i/v and s/c (2 x 10(5) per animal) every 4 days (3 injections in total).

The state of the immune system in thyroidectomized rats.

Disorders in the immune system manifesting in decreased weight and cellularity of lymphoid organs, decreased count of large granular lymphocytes, suppression of the immune response and metabolic activity of macrophages were observed in experimental animals 1-6 months after thyroidectomy. The intensity of these disorders depends on the period elapsed after the surgery. These disorders can result from not only changes in the levels of the pituitary-thyroid hormones, but also disturbances in the endocrine function of the thymus in thyroidectomized animals.

A Trace Element Preparation Increases Antitumor Activity in Mice.

A trace element preparation (Béres Drops Plus, BDP) produced immunomodulatory effects in previous in vitro and in vivo experiments. Here, C57B1/6 inbred mice were transplanted with either Lewis lung tumor or with B16 melanoma. BDP was given intraperitoneally a.