[Changes in immunogenesis organs after thyroidectomy and hormonal correction in an experiment].

Regulating effect of thyroid hormones on functions of organs of the immune system has been demonstrated in the experiment. Deficiency of thyroid hormones affects thymulin synthesis and morphofunctional status of immunogenesis organs. Combination of thymostimulin and thyroxin in the thyroidectomized animals, as compared to their separate use, is pathogenetically the most adequate correcting therapy aiming normalization of structural and functional disorders in the thymus and spleen.

[The mechanism of the immunomodulating action of Béres Drops Plus].

Béres Drops Plus were found to raise the number of E-RFCs, being formed by lymphocytes of peripheral blood of subjects presenting with low levels of T-cells, and to increase the production of substances possessing thymosine-like activity (STLA) by lymphocytes and epithelial cells of the murine thymus gland. In vitro the drug preparation in question enhances endocrine function of thymus in normal animals and the organism's capacity to induce STLA synthesis following thymectomy. These findings are useful in devising rational schemes of rehabilitation of immune system with the drug preparation Béres Drops Plus in secondary immunodeficiency states developing in cases presenting with precancer conditions, malignant neoplasia, in those subjects having taken part in the elimination of the Chernobyl NPP accident aftermath, those residing on the territories controlled, as well as evolving on account of aging.

[The status of the endocrine function of the thymus in acute radiation sickness resulting from the accident at the Chernobyl Nuclear Power Station].

Data are presented on the role of inhibition of endocrine function of the thymus in the pathogenesis of acute radiation sickness resulted from the direct and indirect (via the increased glucocorticoid production) effects of ionizing radiation. The complex treatment, including nonspecific active immunotherapy, permitted to normalize the thymic hormone level and certain parameters of the immune system.