White-coat hypertension and cardiovascular risk.

Objective: To compare cardiovascular risk in white-coat hypertensives, normotensives and established hypertensives.

Methods: We studied 61 hypertensive individuals, 27 of whom were white-coat hypertensives, and 35 normotensives. All subjects underwent 24 h noninvasive blood pressure monitoring and Doppler echocardiographic examination of the heart; urine was tested for microalbuminuria and the fundi of the eyes examined for retinopathy.

Blood pressure pattern importance in the development of left ventricular hypertrophy in hypertension.

Heterogeneous results regarding correlations between blood pressure, (measured by various methods and in different conditions), and left ventricular mass in arterial hypertension have been reported. Fifty-three essential hypertensives, I-II WHO stage, have been studied in order to verify the relationship between office and average 24-hour blood pressure, and its day- and night-time pattern with left ventricular hypertrophy. All patients had newly diagnosed essential hypertension, and no subject had received any antihypertensive therapy before entry.

Reversal of cardiac hypertrophy and left ventricular function with the calcium antagonist felodipine in hypertensive patients.

A study was carried out to evaluate the influence of antihypertensive treatment with a calcium antagonist on left ventricular hypertrophy and to estimate left ventricular performance after reversal of myocardial hypertrophy. Ten essential hypertensives (age 45 +/- 2 years; WHO class II) underwent an M-mode echocardiogram guided by two-dimensional echocardiography, during a wash-out period and after 3, 6 and 12 months of treatment with felodipine ER 10 mg/daily. At month 12 the echocardiogram was also performed during a handgrip test.

[Ketanserin and metoprolol in the treatment of essential hypertension].

In a controlled clinical study, 30 adult patients (16 females, 14 males, mean age 46.0 +/- 7.6, mean body weight 69.

[Microalbuminuria, an early marker of renal changes in essential hypertension].

The purpose of this study was to verify if microalbuminuria (AER) could be an early feature of renal hemodynamic changes in essential hypertension. Fifty-three patients with newly diagnosed essential hypertension (EH) underwent 24-hour blood pressure monitoring (24h-BP). Furthermore, AER and glomerular filtration rate (GFR) were evaluated by obtaining 24-hour urine collection: day- and night-time urine was kept separate.