Publications by authors named "G D'Alterio"
Article Synopsis
- Fluoropyrimidines are vital for cancer treatment but can cause toxic side effects due to the impaired function of the DPYD enzyme, often influenced by genetic variations known as SNPs.
- The study highlights a case where standard genotyping methods failed to accurately identify a specific SNP in an individual of African descent, leading to incorrect interpretations of genetic function.
- The findings emphasize the need for incorporating whole genome sequencing and considering genetic diversity in ethnic populations to ensure accurate pharmacogenetic testing and avoid errors in cancer treatment.
Purpose: Undeniably, in the last 2 decades, surgical approaches in the field of abdominal wall repair have notably improved. However, the best approach to provide a durable repair with low morbidity rate has yet to be determined. The purpose of this study is to outline our long-term results following the Transverse Abdominis Release (TAR) approach in patients with complex ventral hernias, focusing on the incidence of recurrence and overall patient satisfaction following surgery.
View Article and Find Full Text PDFBackground: There are little data on remote monitoring (RM) of implantable loop recorders (ILRs) in patients with unexplained syncope and whether it confers enhanced diagnostic power.
Objective: To evaluate the effect of RM in ILR recipients for unexplained syncope for early detection of clinically relevant arrhythmias by comparison with a historical cohort with no RM.
Methods: SyncRM is a propensity score (PS)-matched study prospectively including 133 consecutive patients with unexplained syncope and ILR followed up by RM (RM-ON group).
Article Synopsis
- This study looked at how heart rates while sleeping and over 24 hours can affect patients with heart problems who use special devices to help their hearts.
- Researchers found that patients with higher heart rates (more than 65 beats while sleeping and over 75 beats in a day) were at a greater risk of serious health problems, like dying or having dangerous heart rhythms.
- The results suggest that keeping heart rates lower can help these patients stay safer and healthier.