Benchmarking cross-species single-cell RNA-seq data integration methods: towards a cell type tree of life.

Cross-species single-cell RNA-seq data hold immense potential for unraveling cell type evolution and transferring knowledge between well-explored and less-studied species. However, challenges arise from interspecific genetic variation, batch effects stemming from experimental discrepancies and inherent individual biological differences. Here, we benchmarked nine data-integration methods across 20 species, encompassing 4.

Co-activating STING-TLR9 pathways promotes radiotherapy-induced cancer vaccination.

Vaccination may cure cancer patients by inducing tumor-specific immune responses. Radiotherapy is an appealing strategy to generate cancer vaccines in situ; thus far, however, only modest and short-lived immune responses are achieved. We here show that radiation combined with co-activating STING-TLR9 can generate powerful in situ cancer vaccines.

Machine learning accelerated nonadiabatic dynamics simulations of materials with excitonic effects.

This study presents an efficient methodology for simulating nonadiabatic dynamics of complex materials with excitonic effects by integrating machine learning (ML) models with simplified Tamm-Dancoff approximation (sTDA) calculations. By leveraging ML models, we accurately predict ground-state wavefunctions using unconverged Kohn-Sham (KS) Hamiltonians. These ML-predicted KS Hamiltonians are then employed for sTDA-based excited-state calculations (sTDA/ML).

Factors and Mechanisms Affecting Arsenic Migration in Cultivated Soils Irrigated with Contained Arsenic Brackish Groundwater.

Contained arsenic (As) and unsafe brackish groundwater irrigation can lead to serious As pollution and increase the ecological risk in cultivated soils. However, little is known about how Fe oxides and microbes affect As migration during soil irrigation processes involving arsenic-contaminated brackish groundwater. In this study, the samples (porewater and soil) were collected through the dynamic soil column experiments to explore the As migration process and its effect factors during soil irrigation.

Comprehensive Analysis of Physicochemical Properties and Sensory Attributes of Original-Cut Potato Chips in the Chinese Market.

This study investigates the Chinese market's physicochemical properties and sensory attributes of 14 original-cut potato chip brands. Color characteristics, compositional analysis, sugar content, acrylamide levels, and textural properties were examined alongside sensory evaluations. Significant variations were observed across all the parameters.