Publications by authors named "G Cros"
Article Synopsis
- The study investigates how flavonoids affect insulin secretion in β-cells, particularly focusing on resokaempferol (ResoK) and its potential benefits for insulin deficiency.
- Researchers tested INS-1 β-cells and pancreatic islets from rats to assess the ability of ResoK to enhance insulin secretion under glucose stimulation.
- Results showed that ResoK increases insulin secretion by stimulating L-type calcium currents, even in dysfunctional β-cells, suggesting it could be a promising treatment strategy for improving insulin secretion.
Article Synopsis
- - Mutations in the RAC2 protein are linked to various immune disorders in patients, including neonatal SCID and infantile diseases resembling leukocyte adhesion deficiency, with 15 new mutations identified among 54 patients studied.
- - The study highlighted that different types of mutations in RAC2 influenced disease outcomes; for instance, certain mutations led to neonatal SCID while others caused later-onset combined immune deficiency or LAD-like diseases.
- - Clinical analysis revealed significant immune system issues among affected patients, including low levels of T and B cells, recurrent infections, and abnormalities in neutrophil function, indicating severe impacts on their immune response.
NOX2 deficiency enhances priming and activation of the NLRP3 inflammasome.
J Allergy Clin Immunol
October 2023
Background: Nicotinamide adenine dinucleotide phosphate oxidase complex 2 (NOX2) deficiency, or chronic granulomatous disease (CGD), is an inborn error of immunity associated with increased susceptibility to infection and inflammatory manifestations. The pathophysiologic mechanism leading to the increased inflammatory response in CGD remains elusive.
Objective: We investigated the pathophysiologic mechanisms leading to NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation in NOX2 deficiency.