Publications by authors named "G Critchley"
Telehealth clinics have been used in many specialities, including neurosurgery, to improve access for patients in rural communities. The introduction of nurse navigators involved with the patient before, during and after the clinic was evaluated. Clinics were held in a rural hospital with a nurse navigator present in the clinic with the patient, and the physician consulting remotely.
View Article and Find Full Text PDFBrain metastases remain a challenging and feared complication for patients with cancer and research in this area has lagged behind research into metastases to other organs. Due to their location and the risks associated with neurosurgical biopsies, the biology underpinning brain metastases response to treatment and evolution over time remains poorly understood. Liquid biopsies are proposed to overcome many of the limitations present with tissue biopsies, providing a better representation of tumor heterogeneity, facilitating repeated sampling, and providing a noninvasive assessment of tumor biology.
View Article and Find Full Text PDFBackground: Extracellular vesicles (EVs) hold promise for improving our understanding of radiotherapy response in glioblastoma due to their role in intercellular communication within the tumour microenvironment (TME). However, methodologies to study EVs are evolving with significant variation within the EV research community.
Methods: We conducted a systematic review to critically appraise EV isolation and characterisation methodologies and how this influences our understanding of the findings from studies investigating radiotherapy and EV interactions in glioblastoma.
The role of medical speciality input in the management of older neurosurgical inpatients.
Br J Neurosurg
September 2023
Article Synopsis
- The elderly population undergoing neurosurgery is increasing, and they often deal with multimorbidity and frailty, which increase postoperative risks.
- A study was conducted to analyze geriatric neurosurgery patients aged 65 and over to see if medical team involvement and frailty scoring impact patient outcomes, focusing on length of stay and mortality.
- Results showed that patients reviewed by medical teams had a significantly shorter length of hospital stay, highlighting the benefits of collaborative care between geriatricians and surgeons for elderly neurosurgical patients.
Background: An increasing proportion of aneurysmal subarachnoid haemorrhage (aSAH) occurs in older patients, in whom there is widespread variability in treatment rates due to a different balance of risks. Our aim was to compare outcomes of patients over 80 years old with good grade aSAH who underwent treatment of their aneurysm with those who did not.
Methods: Adult patients with good grade aSAH admitted to tertiary regional neurosciences centres contributing to the UK and Ireland Subarachnoid Haemorrhage Database (UKISAH) and a cohort of consecutive patients admitted from three regional cohorts were included for analysis.