Publications by authors named "G Cottrell"
Introduction: Recently, efforts to eliminate malaria have shifted focus from symptomatic cases alone to include asymptomatic carriers, who are now recognized as significant contributors to the disease's transmission and control. This study examines the relationship between asymptomatic malaria infection and hemoglobin levels in Benin.
Methods: A cohort in Benin was enrolled and categorized into three age groups (under 5 years, 5-15 years, and over 15 years) for follow-up from August to November 2021.
Introduction: Asymptomatic malaria infection is now recognized as a potential threat to malaria control. However, its prevalence and its dynamics are poorly documented especially in a perennial context of high seasonal transmission. A longitudinal study was conducted in southern Benin to investigate the dynamics of asymptomatic malaria infection and to identify factors influencing it.
View Article and Find Full Text PDFArticle Synopsis
- Dengue is a viral infection spread by mosquitoes, and this study in Benin aimed to investigate the presence of different serotypes beyond the previously recorded DENV serotype 2.
- The research involved analyzing plasma samples from 464 patients for dengue infection using advanced PCR techniques, which led to the identification of DENV-1 and DENV-3 serotypes in three patients.
- This finding highlights the importance of enhancing arbovirus surveillance in Benin, indicating the need for better monitoring of emerging infections.
Objectives: We aimed to evaluate the impact of malaria declaration year (before or after 2017) on the frequency of hospitalization in metropolitan France of patients with uncomplicated non-vomiting P.falciparum malaria.
Patients And Methods: An observational, multicenter, retrospective study was carried out, using the database from the French National Reference Centre for Malaria.
Article Synopsis
- Regulatory T cells (Treg) are crucial for managing immune responses in newborns, especially regarding tolerance to maternal antigens and fighting infections at birth.
- This study, focusing on newborns in West Africa, found that neonates with early-onset sepsis (EOS) had reduced Treg frequency and expression of the Foxp3 marker compared to healthy newborns with prenatal risk factors, indicating a compromised immune profile.
- The findings suggest that specific Treg markers like CTLA-4, PD-1, and CD39 could serve as potential early diagnostic indicators for EOS, as their expression correlates with the severity and outcome of the condition.