Publications by authors named "G Coste"
Article Synopsis
- Generalization helps us apply past experiences to new situations, and the infralimbic (IL) area in the brain is important for this process, although how it works is still not fully understood.
- In an experiment with mice, it was found that manipulating the IL's activity affected their defensive behaviors in response to ambiguous threats: silencing the IL increased generalized freezing, while stimulating it encouraged more vigilant behavior.
- Additionally, researchers identified specific groups of neurons (ensembles) in the IL that were linked to these generalized responses, revealing that these neuronal ensembles help control the degree of generalization when facing uncertain dangers.
Calcification of surgical aortic bioprostheses and its impact on clinical outcome.
Eur Heart J Cardiovasc Imaging
August 2024
Article Synopsis
- Aortic valve calcification (AVC) was studied in patients with bioprosthetic valves to assess its impact on patient prognosis.
- In a study of 361 patients who had valve replacements, AVC was found to be significantly higher in those with structural valve degeneration (SVD).
- The results indicate that AVC greater than 100 Agatston units is correlated with worse health outcomes and increased risk of mortality and cardiovascular events, making CT scans a valuable tool for evaluation.
Safety and Efficacy of Pulmonary Rehabilitation for Long COVID Patients Experiencing Long-Lasting Symptoms.
Int J Environ Res Public Health
February 2024
Due to the high prevalence and persistence of long COVID, it is important to evaluate the safety and efficacy of pulmonary rehabilitation (PR) for patients who experience long-lasting symptoms more than six months after initial COVID-19 onset. Enrolled patients were admitted for a four-week in-patient-PR due to long COVID symptoms (n = 47). The safety of PR was confirmed by the absence of adverse events.
View Article and Find Full Text PDFHippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy.
J Neuropathol Exp Neurol
September 2023
Primary age-related tauopathy (PART) is characterized by aggregation of tau in the mesial temporal lobe in older individuals. High pathologic tau stage (Braak stage) or a high burden of hippocampal tau pathology has been associated with cognitive impairment in PART. However, the potential underlying mechanisms are not well understood.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers developed a deep-learning image-restoration algorithm that enhances both ex vivo and in vivo imaging, improving the ability to visualize synapses in real-time.
- * This new method successfully tracked behavior-related changes in synaptic structures in living transgenic mice with high precision, showcasing the potential of combining advanced imaging techniques for neuroscience research.