Publications by authors named "G Cossa"
Article Synopsis
- - The MYCN oncoprotein works with another protein called MAX to attach to active gene promoters, and it also connects with the nuclear exosome, indicating its role in RNA processing.
- - Research shows that MYCN forms large complexes with the exosome and various RNA-binding proteins, binding to RNA through a specific region known as MYCBoxI, which helps process many intronic RNA transcripts in cells.
- - Disrupting the exosome alters MYCN's position from gene promoters to intronic RNAs, leading to a shift in its role from activating genes to being replaced by a repressor (MNT/MXD6), which can limit its ability to influence cell growth while being crucial for neuroblastoma cell
In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that MYC in PDAC cells is needed for the recruitment of the PAF1c transcription elongation complex to RNA polymerase and that depletion of CTR9, a PAF1c subunit, enables long-term survival of PDAC-bearing mice. PAF1c is largely dispensable for normal proliferation and regulation of MYC target genes.
View Article and Find Full Text PDFRNA-binding proteins emerge as effectors of the DNA damage response (DDR). The multifunctional non-POU domain-containing octamer-binding protein NONO/p54nrb marks nuclear paraspeckles in unperturbed cells, but also undergoes re-localization to the nucleolus upon induction of DNA double-strand breaks (DSBs). However, NONO nucleolar re-localization is poorly understood.
View Article and Find Full Text PDFFall armyworm (FAW), (Smith), is one of the major pests targeted by transgenic crops expressing insecticidal proteins from (Bt) Berliner. However, FAW presents a high capacity to develop resistance to Bt protein-expressing crop lines, as reported in Brazil, Argentina, Puerto Rico and the southeastern U.S.
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