Publications by authors named "G Coskun"
Background: Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular outflow tract obstruction (LVOTO), leading to symptoms and adverse outcomes. Disopyramide, with its negative inotropic effects, is commonly used to reduce LVOTO in obstructive HCM (HOCM). This study evaluates the impact of disopyramide on functional capacity in HOCM patients.
View Article and Find Full Text PDFThird-Hand Smoke Exacerbates HO-Driven Airway Responses in A549 Cells.
Turk J Pharm Sci
November 2024
Article Synopsis
- Third-hand smoke (THS) is harmful residual smoke that remains on surfaces and can negatively affect respiratory health, especially in individuals with preexisting conditions.
- The study investigated how THS causes respiratory toxicity through mechanisms like increased reactive oxygen species (ROS), cytotoxicity, and inflammation in human airway cells.
- Findings indicated that THS leads to oxidative stress, as evidenced by increased levels of malondialdehyde and interleukin-6, along with decreased antioxidant activity, potentially exacerbating respiratory diseases.
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease affecting 1% of the global population, more common in females, and this study examines the anti-inflammatory effects of INSL3, a peptide hormone predominantly found in males.
- The research involved in vivo experiments with male rats treated with varying doses of INSL3 and prednisolone, assessing joint inflammation, severity, and thermal sensitivity, revealing that INSL3 reduced inflammation but was less effective than prednisolone overall.
- In vitro tests on macrophage cells showed that higher doses of INSL3 improved cell viability and morphology, suggesting it could be a supportive treatment alongside existing therapies for RA.
Context: Inflammasome NLR family pyrin domain-containing 3 (NLRP3) is associated with neurological disorders. Neuroinflammation can be suppressed by inhibiting NLRP3 inflammasome activation, decreasing neurodegenerative disorder progression. We devised a therapeutic technique that can reduce neuroinflammation induced by microglial activation, avoiding neurodegeneration.
View Article and Find Full Text PDFEffects of spinal mobilisation in adolescent idiopathic scoliosis: A randomised controlled trial.
J Paediatr Child Health
November 2024
Aim: The aim of this study was to evaluate the effects of spinal mobilisation on curvature magnitude, angle of trunk rotation (ATR) and pulmonary function in adolescents with idiopathic scoliosis (AIS).
Methods: Conducted as a double-blind randomised controlled trial, the study included 40 patients with AIS (Cobb angles 10°-25°) randomised to experimental (n = 20; female = 12, male = 8; age = 12.9 ± 1.