Publications by authors named "G Corte"
Objectives: CD19-targeting chimeric antigen receptor (CAR) T-cell therapy can induce long-term drug-free remission in patients with autoimmune diseases (AIDs). The efficacy of CD19-CAR T-cell therapy is presumably based on deep tissue depletion of B cells; however, such effect has not been proven in humans in vivo.
Methods: Sequential ultrasound-guided inguinal lymph node biopsies were performed at baseline and after CD19-CAR T-cell therapy in patients with AIDs.
Students often struggle with interpreting traditional textbook images and translating them to anatomical structures. This study aimed to compare the impact of 3D scans versus 2D images on students' learning outcomes when learning anatomical structures on skulls from horses and pigs. Furthermore, the correlation between spatial ability and learning outcomes using 3D scans or 2D images was examined.
View Article and Find Full Text PDFObjectives: To assess the presence and anatomical distribution of activated fibroblasts in the joints and entheses of patients with psoriasis with arthralgia and to test how fibroblast activation visualised by gallium-labelled fibroblast activation protein inhibitor-04 (Ga-FAPI-04)-positron emission tomography (PET)/CT correlates with clinical tenderness, musculoskeletal ultrasound findings and progression to psoriatic arthritis (PsA).
Methods: We conducted a prospective cohort study in patients with psoriasis and arthralgia who underwent clinical and ultrasound evaluation and whole-body PET/CT imaging with Ga-FAPI-04. Ga-FAPI-04 uptake at synovial and entheseal sites was assessed by maximal standardised uptake values (SUVmax) and PET/CT Joint Index (JI); logistic regression models were used to investigate its correlation with clinical and ultrasound findings.
Article Synopsis
- ARID1A is a protein that is often changed in different types of cancer and helps fix DNA when it gets damaged.
- When ARID1A is missing, it can cause problems with repairing DNA and lead to more issues in cells, like extra tiny nuclei.
- ARID1A also affects how cells respond to treatments like radiation therapy, making it an important marker for doctors to understand how well a patient's cancer might respond to treatment.
Article Synopsis
- Metabolic shifts and tissue changes happen before visible inflammation in inflammatory rheumatic diseases, making early detection important for managing conditions like arthritis.
- Recent advancements in metabolic imaging techniques, such as nuclear imaging and optical imaging, allow for accurate, non-invasive visualization of metabolic changes related to inflammation.
- These imaging methods have the potential to enhance patient care by enabling early disease interception and personalized treatment strategies in rheumatology, emphasizing the need for further research in this area.