Publications by authors named "G Contant"
Article Synopsis
- ECMO (extracorporeal membrane oxygenation) is linked to a high risk of bleeding, and this study aimed to explore how ECMO affects fibrinolysis markers over time in these patients.
- In the study involving 30 patients, key fibrinolysis markers like tPA and D-dimer increased significantly in bleeding patients before a hemorrhagic event, while nonbleeding patients showed a decreasing trend in these markers.
- Results indicated that higher tPA levels were associated with bleeding events, suggesting that monitoring these fibrinolytic markers could be crucial in managing patients on ECMO.
Background: Blood viscoelasticity and plasma protein levels can play an important role in the diagnosis and prognosis of cancer. However, the role of histones and DNA in modulating blood clot properties remains to be investigated. This study investigates the differences in blood viscoelasticity and plasma protein levels among cancer patients, individuals with other diseases, and healthy individuals.
View Article and Find Full Text PDFBackground: Innovative tools to reliably identify patients with acute stroke are needed. Peripheral monocyte subsets, that is, classical-Mon1, intermediate-Mon2, and non-classical-Mon3, with their activation marker expression analyzed using flow-cytometry (FCM) could be interesting cell biomarker candidates.
Aim: To assess the inter-operator variability in a new peripheral monocyte subset gating strategy using FCM in patients with suspected acute stroke.
Introduction: Andexanet alfa (AnXa) was developed for anticoagulant effect reversal of direct factor Xa inhibitors (DXaI) (apixaban, rivaroxaban, edoxaban) in emergency situations. Regular anti-Xa assays are not suitable to evaluate anti-Xa activity after AnXa administration because of the high sample dilution resulting in the AnXa-DXaI dissociation which gives inaccurately high DXaI measured concentrations. This study aimed at developing dedicated STA-Liquid anti-Xa test set-ups for accurately measuring DXaI after reversal with AnXa.
View Article and Find Full Text PDFIntroduction: Directs oral anticoagulants (DOACs) can interfere with coagulation assays, especially in thrombophilia workup. To avoid these interferences, a new device, DOAC Filter, allows the removal of DOACs from citrated plasma. This study aims to confirm that DOAC Filter efficiently removes DOACs and to ascertain that coagulation assays are not impacted by filtration.
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