Publications by authors named "G Coata"
Article Synopsis
- Study investigates the relationship between urinary levels of S100B and Tau proteins in infants and future neurodevelopmental outcomes, particularly in those born preterm or with intrauterine growth restriction (IUGR).
- Results show that higher levels of S100B and lower levels of Tau in these infants correlate with poorer cognitive and motor skills by age two, though their relation to brain volume is weak.
- The findings suggest that monitoring urinary levels of S100B and Tau, alongside brain growth indicators, could help identify infants at risk for delayed neurodevelopment.
Article Synopsis
- Human amniotic fluid extracellular vesicles (HAF-EVs) from pregnant women show anti-inflammatory effects on T cells and monocytes, but their specific functions are not fully understood.
- * The study aimed to explore how HAF-EVs impact inflammasome activation in human monocytes, finding that these vesicles contain immunoregulatory molecules and small amounts of endotoxin, potentially linked to specific bacterial strains.
- * Results indicate that HAF-EVs can activate inflammasomes in THP-1 cells, but subsequent treatments can inhibit this activation, suggesting HAF-EVs may play a role in immune regulation during early pregnancy.
Pre-eclampsia (PE) is a systemic maternal syndrome affecting 2-8% of pregnancies worldwide and involving poor placental perfusion and impaired blood supply to the foetus. It manifests after the 20 week of pregnancy as new-onset hypertension and substantial proteinuria and is responsible for severe maternal and newborn morbidity and mortality. Identifying biomarkers that predict PE onset prior to its establishment would critically help treatment and attenuate outcome severity.
View Article and Find Full Text PDFFirst trimester HtrA1 maternal plasma level and spontaneous preterm birth.
J Matern Fetal Neonatal Med
February 2022
Objectives: High temperature requirement A1 (HtrA1) is a serine protease detected in maternal plasma and in placental tissues during normal gestation and in various pathological conditions. The purpose of this study was to determine whether the maternal plasma concentration of HtrA1 in first trimester, alone or combined with other maternal factors, can be used to identify women at risk for spontaneous preterm birth (SPTB).
Study Design: This is a cohort study on pregnant women at 12 weeks of gestation recruited between 2014 and 2016 and prospectively followed until delivery.
Introduction: Preeclampsia (PE) is associated with risk of maternal and fetal mortality and morbidity. Several promising predictors of PE have been identified, but early pregnancy screening for PE remains insufficient, and randomized controlled trials that used biomarkers to identify high-risk women have been disappointed. Our aim is to identify a possible early marker of PE.
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