Publications by authors named "G Clark Haynes"
Article Synopsis
- ctDNA (circulating tumor DNA) analysis shows promise in understanding endometrial cancer (EC), revealing significant genetic alterations in advanced/recurrent cases through a study of nearly 2000 patients.
- The study identified that 91.6% of ctDNA samples had somatic mutations, with TP53 being the most frequently altered gene, linked to worse overall survival (OS) for patients.
- Findings suggest that ctDNA testing is a feasible method and could serve as a potential biomarker for monitoring and improving outcomes in endometrial cancer patients.*
Study Design: Cross-sectional study.
Objectives: This study's goal is to report whether Magnetization Transfer Ratio (MTR) can evaluate the severity of white matter (WM) injury in degenerative cervical myelopathy (DCM).
Setting: Laureate Institute of Brain Research, USA; Department of Neurosurgery, University of Oklahoma Health Sciences Center, USA.
Background Context: Degenerative cervical myelopathy (DCM) is characterized by spinal cord atrophy. Accurate estimation of spinal cord atrophy is key to the understanding of neurological diseases, including DCM. However, its clinical application is hampered by difficulties in its precise and consistent estimation due to significant variability in spinal cord morphometry along the cervical spine, both within and between individuals.
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- - Degenerative Cervical Myelopathy (DCM) is a common condition in adults that causes spinal cord dysfunction, often leading to symptoms like weakened coordination and walking difficulties, treated primarily through surgical decompression.
- - Surgical interventions for DCM can be performed through different approaches (anterior, posterior, or hybrid), each with distinct techniques, benefits, and unknown complication risks.
- - The study protocol intends to comprehensively review and analyze existing research on complications from various surgical methods for DCM, by systematically searching medical databases for relevant studies and aggregating the findings to establish stronger evidence.
Many studies have shown that the prevalence of degenerative spinal cord compression increases with age. However, most cases at early stages are asymptomatic, and their diagnosis remains challenging. Asymptomatic cervical spinal cord compression (ASCC) patients are more likely to experience annular tears, herniated disks, and later develop symptomatic compression.
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