Monitoring renal function in obese patients with type 2 diabetes mellitus in daily practice.

Background: Endogenous creatinine clearance (GFR(24-hr)) and the Cockcroft formula (GFR(Cockcroft)) are used for the assessment of the glomerular filtration rate (GFR) in daily practice. The influence of extreme obesity in Type 2 diabetes mellitus (T2DM) on the Cockcroft formula was evaluated.

Methods: We compared GFR as calculated by GFR(Cockcroft) to GFR as determined by GFR(24-hr) in 210 patients with T2DM and normal serum creatinine levels.