Publications by authors named "G Chouvet"
Study Objective: This study was designed to evaluate an unsupervised adaptive algorithm for real-time detection of sleep and wake states in rodents.
Design: We designed a Bayesian classifier that automatically extracts electroencephalogram (EEG) and electromyogram (EMG) features and categorizes non-overlapping 5-s epochs into one of the three major sleep and wake states without any human supervision. This sleep-scoring algorithm is coupled online with a new device to perform selective paradoxical sleep deprivation (PSD).
Article Synopsis
- - Dopamine plays a role in motivation, memory, and reward, but its relationship with vigilance states was unclear prior to this study.
- - Researchers measured dopamine neuron activity in rats during different sleep-wake phases, finding increased activation during paradoxical sleep (PS) that resembled patterns seen during reward consumption.
- - This study challenges the idea that dopamine is not involved in sleep processes, suggesting it may help with memory consolidation during PS, thus offering new insights into sleep physiology and dreaming.
Striatal medium-sized spiny neurons (MSNs) integrate and convey information from the cerebral cortex to the output nuclei of the basal ganglia. Intracellular recordings from anesthetized animals show that MSNs undergo spontaneous transitions between hyperpolarized and depolarized states. State transitions, regarded as necessary for eliciting action potential firing in MSNs, are thought to control basal ganglia function by shaping striatal output.
View Article and Find Full Text PDFThe present study was undertaken to compare the acute and long-term effects of escitalopram and citalopram on rat brain 5-HT neurotransmission, using electrophysiological techniques. In hippocampus, after 2 weeks of treatment with escitalopram (10 mg/kg/day, s.c.
View Article and Find Full Text PDFThe subthalamic nucleus (STN) has been implicated in movement disorders observed in Parkinson's disease because of its pathological mixed burst firing mode and hyperactivity. In physiological conditions, STN bursty pattern has been shown to be dependent on slow wave cortical activity. Indeed, cortical ablation abolished STN bursting activity in urethane-anaesthetized intact or dopamine depleted rats.
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